The level of hydrogen sulfide and morphological changes in the aorta of rats under the influence of vitamin D under the conditions of modulation of the H2S / cystathionine-γ-lyase system

Annotation. Vitamin D and hydrogen sulfide (H2S) belong to pleitropic regulators, which are involved in the control of many cellular functions biochemical processes, determine adaptive potential cardiovascular system. The relationship between vitamin H2S system is not fully investigated. aim study was evaluate effect active form - calcitriol (1,25 (OH)2D3) on morphological state thoracic aorta rats level it’s saturation with under conditions / cystathionine-γ-lyase modulation. experiments were performed 90 white male laboratory accordance principles bioethics (Strasbourg, 1986). 1,25(OH)2D3 administered doses 0.1 μg/kg 1 for 4 weeks. Propargylglycine (50 mg/kg) NaHS (1 used modulate H2S/cystathionine-γ-lyase content determined changes evaluated. Statistical calculations IBM Statistics SPSS 26, differences evaluated Mann-Whitney test at significance p<0.05. It established that 1,25 (OH)2D3 a dose 1.0 leads formation deficiency complex aorta, manifested by damage epithelial cells stromal elements, calcifications. Modulation factor modifies high vessels: increases vascular wall, while increasing tissue has opposite effect. shows ability increase endogenous reduces development pathological blood vessels long-term inhibition